Necrosis is always a pathological and disordered process
The cells die caused by factors that lead to irreversible cell damage
Hypoxia/ischemia/toxic chemical agents
Biological agents/direct damage
A harmful immune response
Such as fungi, bacteria and viruses

State of death
Group of cells
Loss of permeability
Inflammatory response
Coagulation is determined by the denaturation of most
Cellular proteins
Loss of nuclear contour
Loss of nuclear basophilia